MovDisordV3, Main, Exploration, bibRecord, 004381

Monosymptomatic resting tremor and Parkinson's disease: A multitracer positron emission tomographic study

Identifieur interne : 004381 ( Main/Exploration ); précédent : 004380; suivant : 004382

Monosymptomatic resting tremor and Parkinson's disease: A multitracer positron emission tomographic study

Auteurs : Mehran Ghaemi [Allemagne] ; Jan Raethjen [Allemagne] ; Rüdiger Hilker [Allemagne] ; Jobst Rudolf [Allemagne] ; Jan Sobesky [Allemagne] ; Günther Deuschl [Allemagne] ; Wolf-Dieter Heiss [Allemagne]

Source :

Movement Disorders [ 0885-3185 ] ; 2002-07.

RBID : ISTEX:D078FB5AA9457D76B3CB7EE89CEF3CA587952298

Descripteurs français

Pascal (Inist)
- Adulte, Diagnostic différentiel, Etude comparative, Imagerie RMN, Parkinson maladie, Tomographie émission positon, Tremblement repos.
Wicri :
- topic : Adulte.

English descriptors

KwdEn :
- Adult, Aged, Brain (physiopathology), Brain (radionuclide imaging), Cerebellum (physiopathology), Cerebellum (radionuclide imaging), Comparative study, Differential diagnostic, Dihydroxyphenylalanine (analogs & derivatives), Dihydroxyphenylalanine (diagnostic use), Dominance, Cerebral (physiology), Energy Metabolism (physiology), Female, Fluorodeoxyglucose F18 (diagnostic use), Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neurologic Examination, Nuclear magnetic resonance imaging, Parkinson Disease (physiopathology), Parkinson Disease (radionuclide imaging), Parkinson disease, Parkinson's disease, Positron emission tomography, Putamen (physiopathology), Putamen (radionuclide imaging), Raclopride (diagnostic use), Receptors, Dopamine D2 (physiology), Reference Values, Resting tremor, Tomography, Emission-Computed (methods), Tremor (physiopathology), Tremor (radionuclide imaging), Up-Regulation (physiology), monosymptomatic resting tremor, positron emission tomography.
MESH :
- chemical , analogs & derivatives : Dihydroxyphenylalanine.
- chemical , diagnostic use : Dihydroxyphenylalanine, Fluorodeoxyglucose F18, Raclopride.
- methods : Tomography, Emission-Computed.
- physiology : Dominance, Cerebral, Energy Metabolism, Receptors, Dopamine D2, Up-Regulation.
- physiopathology : Brain, Cerebellum, Parkinson Disease, Putamen, Tremor.
- radionuclide imaging : Brain, Cerebellum, Parkinson Disease, Putamen, Tremor.
- Adult, Aged, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neurologic Examination, Reference Values.

Abstract

We sought to elucidate the relationship between monosymptomatic resting tremor (mRT) and Parkinson's disease (PD). We studied eight mRT patients (mean Hoehn and Yahr [H&Y], 1.1 ± 0.4), eight patients with PD (mean H&Y, 1.5 ± 0.8), who showed all three classic parkinsonian symptoms, and seven age‐matched healthy subjects. Subjects underwent cerebral magnetic resonance imaging (MRI) and multitracer positron emission tomography (PET) with 6‐[18F]fluoro‐L‐dopa (F‐dopa), [18F]fluorodeoxyglucose (FDG), and [11C]raclopride (RACLO). PD and mRT patients did not show significant differences in F‐dopa‐, RACLO‐, or FDG‐PET scans. In F‐dopa‐ and RACLO‐PET, significant differences between the pooled patient data and control subjects were found for the following regions: anterior and posterior putamen ipsilateral and contralateral to the more affected body side, and ipsilateral and contralateral putaminal gradients of the Ki values. Furthermore, we found a difference for the normalized glucose values of the whole cerebellum between the control group (0.94 ± 0.06) and PD patients (1.01 ± 0.04; P < 0.05) but not for the mRT group (0.97 ± 0.03). Our findings indicate that monosymptomatic resting tremor represents a phenotype of Parkinson's disease, with a nearly identical striatal dopaminergic deficit and postsynaptic D2‐receptor upregulation in both patient groups. We suggest that the cerebellar metabolic hyperactivity in PD is closer related to akinesia and rigidity rather than to tremor. © 2002 Movement Disorder Society

Url:

https://api.istex.fr/document/D078FB5AA9457D76B3CB7EE89CEF3CA587952298/fulltext/pdf

DOI: 10.1002/mds.10125

Affiliations:

Le document en format XML

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<term>Cerebellum (physiopathology)</term>
<term>Cerebellum (radionuclide imaging)</term>
<term>Comparative study</term>
<term>Differential diagnostic</term>
<term>Dihydroxyphenylalanine (analogs & derivatives)</term>
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<term>Parkinson Disease (radionuclide imaging)</term>
<term>Parkinson disease</term>
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<term>Putamen (radionuclide imaging)</term>
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<term>Receptors, Dopamine D2</term>
<term>Up-Regulation</term>
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<term>Cerebellum</term>
<term>Parkinson Disease</term>
<term>Putamen</term>
<term>Tremor</term>
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<term>Cerebellum</term>
<term>Parkinson Disease</term>
<term>Putamen</term>
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<front><div type="abstract" xml:lang="en">We sought to elucidate the relationship between monosymptomatic resting tremor (mRT) and Parkinson's disease (PD). We studied eight mRT patients (mean Hoehn and Yahr [H&Y], 1.1 ± 0.4), eight patients with PD (mean H&Y, 1.5 ± 0.8), who showed all three classic parkinsonian symptoms, and seven age‐matched healthy subjects. Subjects underwent cerebral magnetic resonance imaging (MRI) and multitracer positron emission tomography (PET) with 6‐[18F]fluoro‐L‐dopa (F‐dopa), [18F]fluorodeoxyglucose (FDG), and [11C]raclopride (RACLO). PD and mRT patients did not show significant differences in F‐dopa‐, RACLO‐, or FDG‐PET scans. In F‐dopa‐ and RACLO‐PET, significant differences between the pooled patient data and control subjects were found for the following regions: anterior and posterior putamen ipsilateral and contralateral to the more affected body side, and ipsilateral and contralateral putaminal gradients of the Ki values. Furthermore, we found a difference for the normalized glucose values of the whole cerebellum between the control group (0.94 ± 0.06) and PD patients (1.01 ± 0.04; P < 0.05) but not for the mRT group (0.97 ± 0.03). Our findings indicate that monosymptomatic resting tremor represents a phenotype of Parkinson's disease, with a nearly identical striatal dopaminergic deficit and postsynaptic D2‐receptor upregulation in both patient groups. We suggest that the cerebellar metabolic hyperactivity in PD is closer related to akinesia and rigidity rather than to tremor. © 2002 Movement Disorder Society</div>
</front>
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</country>
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Movement Disorders (revue)

Monosymptomatic resting tremor and Parkinson's disease: A multitracer positron emission tomographic study

Monosymptomatic resting tremor and Parkinson's disease: A multitracer positron emission tomographic study

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.